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Directed Evolution of an AAV9 Library Identifies a Capsid Variant with Enhanced Brain Tropism and Liver De-Targeting in Non-Human Primates and Mice Following Systemic Administration

Tyler Moyer, Kristin Graham,Jiachen Liu,Xiaoqin Ren,Joseph Clement, Alexis Bloedel,Anupriya Kulkarni, Kailyn Looby, Hamza Khalid,Bruce Amy, Chiso Egbuchulam,Dan Laks,Matthew Child,Rupinderjit Kaur,Ambreen Sayed-Zahid, Michael Grannan,Charlotte Chung,Tatiana Knox, Brett Hoffman,Alex Kutchin,Amy Johnson, Andrew Cameron,Kyle Grant,Johnny Yao,Nilesh Pande,Jeff Thompson,Garrett Heffner, Todd A. Carter,Mathieu E. Nonnenmacher

MOLECULAR THERAPY（2023）

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