Towards a Science-Based Testing Strategy to Identify Maternal Thyroid Hormone Imbalance and Neurodevelopmental Effects in the Progeny—part III: How is Substance-Mediated Thyroid Hormone Imbalance in Pregnant/lactating Rats or Their Progeny Related to Neurodevelopmental Effects?
Critical reviews in toxicology（2022）
关键词
Thyroxine (T4),triiodothyronine (T3),developmental neurotoxicity (DNT) study (OECD TG 426),motor activity,acoustic startle response,cognitive function (learning and memory),extended one generation reproductive toxicity study (EOGRTS,OECD TG 443),thyroid peroxidase (TPO),sodium-iodide symporter (NIS),deiodinase (DIO),uridine diphosphate glucuronyltransferase (UGT),thyroid hormone clearance,adverse outcome pathway (AOP),mode-of-action (MoA)
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