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Phase Separation in Cgas‐sting Signaling: Cytosolic DNA Sensing and Regulatory Functions

Chembiochem(2023)SCI 4区

East China University of Science and Technology | National Institute for Parasitic Diseases

Cited 3|Views5
Abstract
Phase separation is a crucial biophysical process that governs cellular signaling and function. This process allows biomolecules to separate and form membraneless compartments in response to both extra- and intra-cellular stimuli. Recently, the identification of phase separation in different immune signaling pathways, including the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway, has shed light on its tight association with pathological processes such as viral infections, cancers, and inflammatory diseases. In this review, we present the phase separation in cGAS-STING signaling, along with its related cellular regulatory functions. Furthermore, we discuss the introduction of therapeutics targeting cGAS-STING signaling, which plays a pivotal role in cancer progression.
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Key words
cGAS-STING pathway,DNA sensing,immune response,immunotherapy,phase separation
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