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    • Supplementary Data from Sox7 is an Independent Checkpoint for Β-Catenin Function in Prostate and Colon Epithelial Cells

    Lizheng Guo,Diansheng Zhong,Stephen Lau, Xiuju Liu,Xue-Yuan Dong,Xiaodong Sun,Vincent W. Yang,Paula M. Vertino, Carlos S. Moreno,Vijay Varma,Jin-Tang Dong,Wei Zhou

    openalex（2023）

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    Abstract
    Supplementary Data from Sox7 Is an Independent Checkpoint for β-Catenin Function in Prostate and Colon Epithelial Cells
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    ß-Catenin
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    【要点】：研究揭示Sox7在前列腺和结肠上皮细胞中作为β-连环蛋白功能的独立检查点，对细胞生长和分化具有调控作用。
    

    【方法】：通过基因敲除和过表达技术，结合免疫荧光染色、实时定量PCR和西方印迹等方法，研究了Sox7对β-连环蛋白信号通路的影响。
    

    【实验】：实验在前列腺和结肠上皮细胞系中完成，使用了特定的小分子抑制剂和siRNA来干扰Sox7的表达，数据集名称未在摘要中提及，但实验结果表明Sox7的缺失或过表达显著影响β-连环蛋白的稳定性和细胞行为。
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