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A Microbial Platform for Recyclable Plastics with Customizable Properties

openalex(2023)

University of California | Lawrence Berkeley National Laboratory | UC Berkeley | LBNL | Technical University of Denmark | Lawrence Berkeley Lab | Lawrence Berkeley National Lab

Cited 1|Views34
Abstract
Abstract Plastics have played a crucial role in shaping the modern era. However, they are produced almost exclusively from non-renewable feedstocks and face considerable challenges in recycling, especially crosslinked polymers used in consumer electronics, building materials, automotive parts, and aerospace composites1–3. Here, we integrate computational materials design, polymer chemistry, synthetic biology, and systems analysis into a workflow to accelerate the design of biorenewable polydiketoenamines (bioPDKs) with tailored properties and circularity through molecular engineering of their monomers, which are derived from β-keto-δ-lactones (BKDLs). Our approach leverages the modular assembly of hybrid polyketide synthases (PKSs) to enable the biosynthesis of BKDLs with diverse substituents at the γ- and δ-positions with defined stereochemistry. We exploit these features to tailor bioPDK hydrophobicity and depolymerization temperature in aqueous acid, which would be nearly impossible to do at scale using synthetic chemistry. In specific designs, we observe increases in bioPDK acidolysis above thresholds for comparable PDK materials derived from petrochemicals, which has implications for mixed-plastic and composite recycling, solvent and chemical resistance, and degradation.
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Biodegradable Polymers,Sustainable Polymers,Polyester Synthases,Nano-composites
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要点】:该论文提出了一种微生物平台,通过改造β-keto-δ-lactones(BKDLs)单体,加速设计具有可回收性和定制性质的生物可再生聚二酮胺(bioPDKs),创新性地结合了计算材料设计、聚合物化学、合成生物学和系统分析。

方法】:该研究采用模块化组装的杂合聚酮合成酶(PKSs)策略,实现对BKDLs单体的生物合成,从而定制bioPDK的性质。

实验】:研究通过改造bioPDK的水解酸性条件下的聚合和解聚特性,观察到某些设计下的bioPDK在酸性条件下的水解性能优于传统石油化学PDK材料,对于混合塑料和复合材料的回收、溶剂和化学品耐受性以及降解性具有积极影响,实验使用的是特定的bioPDK数据集。