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    • EP08.03-01 Copy Number Variants and Late Somatic Mutations Underlying Tumor Progression in NADIM Clinical Trials

    R. Serna Blasco,M. R. Garcia Campelo,E. Nadal,P. Mediavilla,V. Calvo,J. L. Gonzalez-Larriba,L. Robado de Lope,B. Massuti,A. Martinez-Marti,J. Casal,M. Domine,M. Cobo,A. Cruz, A. Romero,M. Provencio

    Journal of Thoracic Oncology（2023）SCI 1区

    Hosp Univ Puerta Hierro Majadahonda | Complexo Hosp Univ A Coruna | Inst Catala Oncol | Hosp Univ Clin San Carlos | Hosp Gen Univ Dr Balmis Alicante | Hosp Univ & Inst Oncol Vall dHebron VHIO | Complexo Hosp Univ Vigo | Hosp Univ Fdn Jimenez Diaz IIS FJD | Hosp Reg Univ Malaga

    Cited 0|Views14
    Abstract
    Neoadjuvant chemoimmunotherapy is the new standard of treatment for locally-advanced (stage IIIA-B) non-small-cell lung cancer (NSCLC) patients. In this study, we report preliminary results of potential molecular mechanisms underlying disease progression in patients treated with neoadjuvant nivolumab plus chemotherapy using plasma samples from NADIM and NADIM II cohorts.
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    NADIM clinical trials,Neoadjuvant treatment,progression
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
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    【要点】：本文探讨了新辅助化疗免疫疗法治疗局部晚期非小细胞肺癌患者过程中疾病进展的潜在分子机制，发现了与肿瘤进展相关的拷贝数变异和晚期体细胞突变。
    

    【方法】：研究采用血浆样本，运用分子生物学技术分析NADIM和NADIM II队列患者的基因变异。
    

    【实验】：实验使用了NADIM和NADIM II临床试验中的血浆样本，通过分析获得了疾病进展的相关分子机制初步结果。