Revealing the Mechanism of Action of a First-in-class Covalent Inhibitor of KRASG12C (ON) and Other Functional Properties of Oncogenic KRAS by 31P NMR

Alok K. Sharma, Jun Pei,Yue Yang,Marcin Dyba,Brian Smith,Dana Rabara,Erik K. Larsen,Felice C. Lightstone,Dominic Esposito,Andrew G. Stephen, Bin Wang,Pedro J. Beltran,Eli Wallace,Dwight V. Nissley,Frank McCormick,Anna E. Maciag

The Journal of biological chemistry（2024）

Cited 5|Views37

Key words

GTPase KRAS,Cancer,nucleotide,state 1 (inactive) conformation,state 2 (active) conformation,31P NMR,GTP,GppNHp,KRAS G12C selective small molecule inhibitor,Protein complex

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