Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.
Wai Ling Cheung-Lee,Joshua N. Kolev,John A. Mcintosh, Agnieszka A. Gil,Weilan Pan,Li Xiao,Juan E. Velasquez,Rekha Gangam,Matthew S. Winston,Shasha Li, Kotoe Abe,Embarek Alwedi,Zachary E. X. Dance, Haiyang Fan,Kaori Hiraga,Jungchul Kim,Birgit Kosjek,Diane N. Le,Nastaran Salehi Marzijarani,Keith Mattern,Jonathan P. Mcmullen,Karthik Narsimhan, Ajit Vikram,Wei Wang,Jia-Xuan Yan,Rong-Sheng Yang, Victoria Zhang,Wendy Zhong,Daniel A. Dirocco,William J. Morris,Grant S. Murphy,Kevin M. Maloney ANGEWANDTE CHEMIE-INTERNATIONAL EDITION（2024）
关键词
Hydroxylation,Biocatalysis,Directed Evolution,Enzyme Engineering,alpha-ketoglutarate-dependent dioxygenase
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