Synthesis of Nirmatrelvir: Development of a Scalable Cobalt-Catalyzed Cyclopropanation for Manufacture of the Bicyclic [3.1.0]Proline-Building Block

Russell F. Algera,Christophe Allais,Aaron F. Baldwin, Torsten Busch, Federica Colombo, Matteo Colombo, Christelle Depretz, Yves Rene Dumond, Andres R. Faria Quintero, Maria Heredia, Jorg Jung, Amrita Lall,Taegyo Lee,Yizhou Liu, Stefano Mandelli, Marvin Mantel,Ronald Morris,Jason Mustakis, Bao Nguyen, Robert Pearson,Jared L. Piper,John A. Ragan, Brigitte Ruffin, Courtney Talicska,Sergei Tcyrulnikov,Christopher Uyeda,R. Matthew Weekly, Ming Zeng

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2023）

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Key words

nirmatrelvir,cyclopropanation,cobalt,bicyclic amine

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