NEDD4L Intramolecular Interactions Regulate Its Auto- and Substrate NaV1.5 Ubiquitination

Katharine M. Wright,Sara Nathan,Hanjie Jiang, Wendy Xia, HyoJeon Kim,Nourdine Chakouri,Justin N. Nwafor,Lucile Fossier,Lakshmi Srinivasan,Zan Chen,Tatiana Boronina,Jeremy Post,Suman Paul,Robert N. Cole,Manu Ben-Johny,Philip A. Cole,Sandra B. Gabelli

The Journal of biological chemistry（2024）

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关键词

NEDD4L,NEDD4-2,HECT,E3 Ligases,Ubiquitin,Nav1.5,SCN5A,Voltage-Gated Sodium Channel,post translational modification,PTM,transthioesterification,proteostasis,mass spectrometry,electrophysiology,nanobody,NanoMaN

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