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Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium Falciparum Drug Target, Prolyl-Trna-Synthetase

Stephen Nakazawa Hewitt,David M. Dranow,Benjamin G. Horst,Jan A. Abendroth,Barbara Forte,Irene Hallyburton,Chimed Jansen,Beatriz Baragana,Ryan Choi,Kasey L. Rivas,Matthew A. Hulverson,Mitchell Dumais,Thomas E. Edwards,Donald D. Lorimer,Alan H. Fairlamb,David W. Gray,Kevin D. Read,Adele M. Lehane,Kiaran Kirk,Peter J. Myler,Amy Wernimont,Chris Walpole,Robin Stacy,Lynn K. Barrett,Ian H. Gilbert,Wesley C. Van Voorhis

ACS INFECTIOUS DISEASES（2017）

Cited 47|Views39
Key words
Plasmodium falciparum,drug screening,prolyl-tRNA-synthetase,high-throughput screening,halofuginone,antimalarials
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