Discovery of Pyridopyrimidinones That Selectively Inhibit the H1047R PI3Kα Mutant Protein.
John M. Ketcham,Stephen J. Harwood,Ruth Aranda, Athenea N. Aloiau, Briana M. Bobek,David M. Briere,Aaron C. Burns,Kersti Caddell Haatveit,Andrew Calinisan,Jeffery Clarine, Adam Elliott,Lars D. Engstrom,Robin J. Gunn,Anthony Ivetac,Benjamin Jones,Jon Kuehler,J. David Lawson,Natalie Nguyen,Cody Parker,Kelly E. Pearson,Lisa Rahbaek,Barbara Saechao,Xiaolun Wang, Anna Waters,Laura Waters, Ashlee H. Watkins,Peter Olson,Christopher R. Smith,James G. Christensen,Matthew A. Marx Journal of Medicinal Chemistry（2024）
Key words
PI3K/AKT pathway
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