Supplementary Figure S5 from A Composite Decision Rule of CD8+ T-cell Density in Tumor Biopsies Predicts Efficacy in Early-stage, Immunotherapy Trials

David Dejardin,Anton Kraxner,Annika Blank,Natascha Rieder,Volker Teichgräber,Nicolas Städler,Ulrich Beyer,Bruno Gomes,Jehad Charo

openalex（2024）

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Abstract

Higher response rate in groups above CD8 density threshold.

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Key words

Tumor Microenvironment,Intratumor Heterogeneity,Tumor Dynamics,Cancer Immunoediting,T-cell Exhaustion

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【要点】：本文提出了一种基于肿瘤活检中CD8+ T细胞密度的复合决策规则，用以预测早期阶段免疫治疗试验的疗效，创新点在于通过CD8+ T细胞密度作为生物标志物来评估免疫治疗的响应率。

【方法】：作者通过分析肿瘤活检样本中的CD8+ T细胞密度，结合其他临床和病理特征，构建了一个复合决策规则。

【实验】：研究使用了来自早期阶段免疫治疗试验的数据集，通过统计分析得出高于CD8密度阈值的组别显示出更高的响应率。

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