Scalable Synthesis of C5aR1 Antagonist ACT-1014-6470 Via N 7-Selective Reductive Amination of an Unprotected Pyrazole Starting Material and Intramolecular Urea Formation with 1,1′-Carbonyl-di(1,2,4-triazol) (CDT)
ORGANIC PROCESS RESEARCH & DEVELOPMENT（2024）
Key words
reductive amination,pyrazole,amidereduction,DEANB,CDT,urea formation
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