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Efficient Large-Scale Exploration of Fragment Hit Progression by Exploiting Binding-Site Purification of Actives (B-SPA) Through Combining Multi-Step Array Synthesis and HT Crystallography.

Harold Grosjean,Anthony Aimon,Storm Hassell-Hart,Warren Thompson,Lizbé Koekemoer, James Bennett, Cameron Anderson,Conor Wild,William Bradshaw,Edward A FitzGerald, Tobias Krojer,Anthony Bradley,Oleg Fedorov, Philip C. Biggin,John Spencer,Frank von Delft

openalex（2024）

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Drug Target Identification,Click Chemistry
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