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    • NCCN Guidelines® Insights: Prostate Cancer, Version 3.2024.

    Journal of the National Comprehensive Cancer Network JNCCN（2024）

    1Robert H. Lurie Comprehensive Cancer Center of Northwestern University. | 2Stanford Cancer Institute. | 3Indiana University Melvin and Bren Simon Comprehensive Cancer Center. | 4Yale Cancer CenterSmilow Cancer Hospital. | 5Duke Cancer Institute. | 6The University of Texas MD Anderson Cancer Center. | 7Fred Hutchinson Cancer Center. | 8Dana-FarberBrigham and Women's Cancer Center. | 9UT Southwestern Simmons Comprehensive Cancer Center. | 10City of Hope National Cancer Center. | 11Memorial Sloan Kettering Cancer Center. | 12Prostate Health Education Network (PHEN). | 13Mass General Cancer Center. | 14Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute. | 15Abramson Cancer Center at The University of Pennsylvania. | 16Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine. | 17Mayo Clinic Comprehensive Cancer Center. | 18Roswell Park Comprehensive Cancer Center. | 19University of Wisconsin Carbone Cancer Center. | 20The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. | 21UC San Diego Moores Cancer Center. | 22University of Michigan Rogel Cancer Center. | 23Moffitt Cancer Center. | 24UCLA Jonsson Comprehensive Cancer Center. | 25UCSF Helen Diller Family Comprehensive Cancer Center. | 26University of Colorado Cancer Center. | 27University of California San Francisco Patient Services Committee. | 28The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute. | 29The UChicago Medicine Comprehensive Cancer Center. | 30Fred & Pamela Buffett Cancer Center. | 31Huntsman Cancer Institute at the University of Utah. | 32UC Davis Comprehensive Cancer Center. | 33Fox Chase Cancer Center. | 34National Comprehensive Cancer Network.

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    Abstract
    The NCCN Guidelines for Prostate Cancer include recommendations for staging and risk assessment after a prostate cancer diagnosis and for the care of patients with localized, regional, recurrent, and metastatic disease. These NCCN Guidelines Insights summarize the panel's discussions for the 2024 update to the guidelines with regard to initial risk stratification, initial management of very-low-risk disease, and the treatment of nonmetastatic recurrence.
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
    • We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
    • We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
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    • Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance
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