Fast T1 Mapping MRI in Preclinical and Clinical Settings Using Subspace-Constrained Joint-Domain Reconstructions

Lingceng Ma,Qingjia Bao,Ricardo P. Martinho,Zhong Chen,Lucio Frydman

MAGNETIC RESONANCE LETTERS（2024）

Weizmann Inst Sci | Xiamen Univ

Cited 0|Views8

Abstract

This work aims to develop fast T1 mapping methods for preclinical and clinical scanners based on subspace-constrained reconstructions. Two sequences are explored for rapid T1 characterizations: 1) Interleaved spatiotemporal encoding incorporating variable repetition times. 2) Inversion recovery gradient echo with random sampling of the phase-encoding (PE) dimension. For both sequences, the subspace reconstruction of the signal recovery was applied, to jointly reconstruct the down-sampled images while characterizing the T1 relaxation. In vivo scans on human brains and abdomens confirmed the efficiency of the proposed methods, including compatibility with breath-holding. In addition, Scans on animals with abdominal tumors and dynamic contrast-enhanced T1 mapping on kidneys support the applicability of the proposed methods also in preclinical settings.

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Key words

T1 mapping,Subspace-constrained reconstructions,IR GRE,SPEN,Dynamic contrast enhancement,Pancreatic cancer

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