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Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib

Robert D. Franklin,Travis Armiger,Douglas A. L. Otte,Reed T. Larson,Glenn Spencer, Pratiq A. Patel, Mellie June Paulines, Jackson R. Hall,Kai-Jiong Xiao,Patrick S. Fier, Vailankanni L. Rodrigues,Erik D. Guetschow,Nadine Kuhl,Lisa Jellett,James Corry,Cheol K. Chung,David A. Thaisrivongs

Organic Process Research & Development（2024）

引用 1|浏览22
关键词
Flow Chemistry,Pharmaceutical,Scale-up,Organolithium
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