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Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation As a Batch–Flow Process

Douglas A. L. Otte,Reed T. Larson,Embarek Alwedi,Travis Armiger,Yonggang Chen,Cheol K. Chung,James Corry,Richard Desmond,Patrick S. Fier, Robert D. Franklin,Erik D. Guetschow, Jackson R. Hall,Holst M. Halsey,Clara Hartmanshenn,Lisa Jellett,Nadine Kuhl,Francois Levesque,Jonathan P. McMullen, Pratiq A. Patel, Mellie June Paulines,Hong Ren, Vailankanni L. Rodrigues,Serge Ruccolo,Lushi Tan,David A. Thaisrivongs,Kai-Jiong Xiao

Organic Process Research & Development（2024）

Cited 1|Views18
Key words
flow,fluidics,reactive intermediate,CSTR,continuously stirred,PFR,plugflow
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