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A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule

Iraj Hosseini,Brett Fleisher,Jennifer Getz,Jeremie Decalf,Mandy Kwong,Meric Ovacik,Travis W. Bainbridge,Christine Moussion,Gautham K. Rao,Kapil Gadkar,Amrita V. Kamath,Saroja Ramanujan

PHARMACEUTICS（2024）

Cited 0|Views18
Key words
expansion-enhanced target-mediated drug disposition (TMDD),FLT3L,first-in-human (FIH) dose,model-informed drug development (MIDD)
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