CXCL16-dependent Scavenging of Oxidized Lipids by Islet Macrophages Promotes Differentiation of Pathogenic CD8+ T Cells in Diabetic Autoimmunity

Neetu Srivastava, Hao Hu,Orion J. Peterson,Anthony N. Vomund,Marta Stremska, Mohammad Zaman, Shilpi Giri,Tiandao Li,Cheryl F. Lichti,Pavel N. Zakharov,Bo Zhang,Nada A. Abumrad,Yi-Guang Chen,Kodi S. Ravichandran,Emil R. Unanue,Xiaoxiao Wan

Immunity（2024）

引用 4|浏览18

关键词

tissue-resident macrophages,autoimmunity,type 1 diabetes,CXCL16,oxidized LDL,pancreatic islets,CD8 T cell exhaustion,CD8 T cell differentiation,CD8 T cell ferroptosis,PD-1 checkpoint blockade

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