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The Efficient Synthesis of Pregabalin with Impurity Control Using a Continuous Flow System.

Fengfeng Yan, Kailang Liu, Jingwei Zhang, Tao Zhou,Jinpei Huang,Fajun Wang,Cheng Qi,Jianhong Xu,Sunliang Cui,An Chen

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION（2024）

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Key words
Microreactor system,Pregabalin synthesis,Hofmann rearrangement,Impurity control
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