Reconstruction of TNF-α with Specific Isoelectric Point Released from SPIONs Basing on Variable Charge to Enhance Ph-Sensitive Controlled-Release

Lin Yan, Yadi Chen, Shihao Zhang, Chunjie Zhu, Shangying Xiao, Haishan Xia, Xiaohua Chen, Dan Guo,Xiaohua Lv,Lei Rao,Manjiao Zhuang

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE（2024）

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Key words

TNF-alpha,SPION,pH-sensitive controlled release,Isoelectric point,Tumor microenvironment

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