TRIM21 and Fc-engineered Antibodies: Decoding Its Complex Antibody Binding Mode with Implications for Viral Neutralization

Johannes Reusch, Linda Elise Franken, Jakob Then,Philippe Ringler, Joachim Butzer, Thomas Juroschek,Christian Klein,Tilman Schlothauer,Laurent Lariviere

Frontiers in Immunology（2024）

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TRIM21,therapeutic IgG,antibody Fc mutants,antibody mediated viral neutralization,binding kinetics,affinity,avidity,structure-function

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