Fc-engineered Large Molecules Targeting Blood-Brain Barrier Transferrin Receptor and CD98hc Have Distinct Central Nervous System and Peripheral Biodistribution Compared to Standard Antibodies Nathalie Khoury , Michelle E Pizzo , Claire B Discenza , David Joy , David Tatarakis , Mihail Ivilinov Todorov , Moritz Negwer , Connie Ha , Gabrielly L De Melo , Lily Sarrafha , Matthew J Simon , Darren Chan , Roni Chau , Kylie Chew , Johann Chow , Allisa Clemens , Yaneth Robles-Colmenares , Jason C Dugas , Joseph Duque , Doris Kaltenecker , Holly Kane , Amy Leung , Edwin Lozano , Arash Moshkforoush , Elysia Roche , Thomas Sandmann , Mabel Tong , Kaitlin Xa , Yinhan Zhou , Joseph W Lewcock , Ali Ertürk , Robert G Thorne , Meredith E K Calvert , Y Joy Yu Zuchero biorxiv（2024）
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