Design and Validation of the ADNI MR Protocol

Arvin Arani,Bret Borowski, John Felmlee,Robert I Reid,David L Thomas,Jeffrey L Gunter,Lara Stables,Randy L Buckner,Youngkyoo Jung,Duygu Tosun,Michael Weiner,Clifford R Jack,Alzheimer's Disease Neuroimaging Initiative

Alzheimer's & dementia the journal of the Alzheimer's Association（2024）

Department of Radiology | Department of Brain Repair and Rehabilitation | Department of Radiology and Biomedical Imaging | Department of Psychology | Department of Biomedical Engineering

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Abstract

Phase four of the Alzheimer's Disease Neuroimaging Initiative (ADNI4) magnetic resonance imaging (MRI) protocols aim to maintain longitudinal consistency across two decades of data acquisition, while adopting new technologies. Here we describe and justify the study's design and targeted biomarkers. The ADNI4 MRI protocol includes nine MRI sequences. Some sequences require the latest hardware and software system upgrades and are continuously rolled out as they become available at each site. The main sequence additions/changes in ADNI4 are: (1) compressed sensing (CS) T1-weighting, (2) pseudo-continuous arterial spin labeling (ASL) on all three vendors (GE, Siemens, Philips), (3) multiple-post-labeling-delay ASL, (4) 1 mm3 isotropic 3D fluid-attenuated inversion recovery, and (5) CS 3D T2-weighted. ADNI4 aims to help the neuroimaging community extract valuable imaging biomarkers and provide a database to test the impact of advanced imaging strategies on diagnostic accuracy and disease sensitivity among individuals lying on the cognitively normal to impaired spectrum. HIGHLIGHTS: A summary of MRI protocols for phase four of the Alzheimer's Disease Neuroimaging Initiative (ADNI 4). The design and justification for the ADNI 4 MRI protocols. Compressed sensing and multi-band advances have been applied to improve scan time. ADNI4 protocols aim to streamline safety screening and therapy monitoring. The ADNI4 database will be a valuable test bed for academic research.

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【要点】：本文介绍了ADNI4项目的设计与验证，旨在通过更新MRI协议，保持数据采集的纵向一致性，并引入新技术以提取有价值的神经影像生物标志物，提高诊断准确性和疾病敏感性。

【方法】：文章描述了ADNI4 MRI协议的设计和选择特定生物标志的理由，包括九种MRI序列，并针对压缩感知技术和多波段技术的应用进行了优化。

【实验】：ADNI4 MRI协议在多个站点实施，使用包括CS T1加权、伪连续动脉自旋标记(ASL)、多后标记延迟ASL、1mm3各向同性3D流体衰减反转恢复和CS 3D T2加权在内的序列，具体实验结果待从ADNI4数据库中提取以评估先进成像策略对诊断准确性和疾病敏感性的影响。