Combination Anti-Pd-1 and Anti-Ctla-4 Therapy Generates Waves of Clonal Responses That Include Progenitor-Exhausted CD8+ T Cells

Kevin Wang,Paulina Coutifaris, David Brocks,Guanning Wang, Tarek Azar,Sabrina Solis,Ajeya Nandi, Shaneaka Anderson,Nicholas Han,Sasikanth Manne, Evgeny Kiner,Chirag Sachar, Minke Lucas,Sangeeth George,Patrick K. Yan, Melanie W. Kier, Amy I. Laughlin,Shawn Kothari,Josephine Giles,Divij Mathew,Reem Ghinnagow,Cecile Alanio,Ahron Flowers,Wei Xu,Daniel J. Tenney,Xiaowei Xu,Ravi K. Amaravadi,Giorgos C. Karakousis,Lynn M. Schuchter,Marcus Buggert,Derek Oldridge,Andy J. Minn,Christian Blank,Jeffrey S. Weber,Tara C. Mitchell,Michael D. Farwell,Ramin S. Herati,Alexander C. Huang

CANCER CELL（2024）

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关键词

Checkpoint blockade,T cell exhaustion,PD-1 blockade,CTLA-4 blockade,single-cell sequencing,combination checkpoint blockade,progenitor exhausted CD8+ T cells,clonotypic analysis,melanoma,immunotherapy

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