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Imaging-free, Few-Shot, Three-Dimensional Focusing on Point-Like Emitters in Confocal Microscopy

Swetapadma Sahoo, Junyue Jiang, Jaden Li, Kieran Loehr, Chad E. Germany, Jincheng Zhou, Bryan K. Clark,Simeon I. Bogdanov

2024 Conference on Lasers and Electro-Optics (CLEO)(2024)

Zhejiang University-University of Illinois at Urbana-Champaign Institute

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Abstract
We introduce a rapid, noise-robust, three-dimensional focusing framework for as-is confocal microscopes. We show automated real-time focusing on nanoscale emitters for SNR down to 1, and position tracking with a precision below 10 nm.
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Key words
Confocal Microscopy,Point-like Emitter,Position Tracking,Monte Carlo Simulation,Finite Difference,Point Spread Function,Target Zone,Ground Truth Information,Piezo Stage
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要点】:本文提出了一种无需成像、少样本、三维聚焦方法,实现了在信噪比低至1的情况下对纳米尺度发射体的实时自动聚焦和低于10纳米的精确定位跟踪。

方法】:研究采用了一种新型的三维聚焦框架,通过无需成像的方式,在传统共聚焦显微镜上实现了对点状发射体的高效聚焦。

实验】:实验在真实共聚焦显微镜上完成,使用特定信噪比条件下的纳米尺度发射体作为测试样本,成功实现了高精度的聚焦和定位,具体数据集名称未在摘要中提及。