Optimized Whole-Slide-Image H&e Stain Normalization: A Step Towards Big Data Integration in Digital Pathology

Jose L. Agraz, Carlos Agraz,Andrew A. Chen, Charles Rice,Robert S. Pozos, Sven Aelterman, Amanda Tan,Angela N. Viaene,MacLean P. Nasrallah, Parth Sharma,Caleb M. Grenko,Tahsin Kurc,Joel Saltz,Michael D. Feldman,Hamed Akbari,Russell T. Shinohara,Spyridon Bakas, Parker Wilson

IEEE OPEN JOURNAL OF ENGINEERING IN MEDICINE AND BIOLOGY（2025）

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Key words

Vectors,Standards,Image color analysis,Medical diagnostic imaging,Pathology,Histograms,Euclidean distance,Glioblastoma,normalization,optimizing,preprocessing,stain-vectors,whole-slide-image

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