DiPTAC: A Degradation Platform Via Directly Targeting Proteasome
Acta Pharmaceutica Sinica B（2024）
Abstract
To the Editor: Targeted protein degradation(TPD)has emerged as a powerful therapeutic strategy for the treatment of various diseases,including cancer,that are associated with aberrant high levels of pathogenic proteins1.Recently,several strategies have been investigated to address TPD,including targeting E2,E3 for POI degradation2,or employing DUBs to stabilize POI3.Among them,proteolysis targeting chimeras(PROTACs)have emerged as the predominant approach in both preclinical and clinical in-vestigations by connecting an E3 recruiting ligand to a POI ligand4.
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Key words
Targeted protein degradation,PROTAC,E3,Proteasome,DiPTAC
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