Open-Source Throttling of CD8+ T Cells in Brain with Low-Intensity Focused Ultrasound-Guided Sequential Delivery of CXCL10, IL-2, and Apd-L1 for Glioblastoma Immunotherapy

Lei Dong, Yini Zhu, Haoge Zhang, Lin Gao,Zhiqi Zhang,Xiaoxuan Xu,Leqian Ying, Lu Zhang, Yue Li, Zhengcheng Yun, Danqi Zhu, Chang Han, Tingting Xu, Hui Yang,Shenghong Ju,Xiaoyuan Chen, Haijun Zhang,Jinbing Xie

Advanced Materials（2024）

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CXCL10,glioblastoma,IL-2,immune checkpoint inhibitors,immunosuppressive microenvironment,low-frequency focused ultrasound,T-cell exhaustion

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