Towards a Universal Method for Middle-Down Analysis of Antibodies Via Proton Transfer Charge Reduction—orbitrap Mass Spectrometry

Ryan N. Oates,Linda B. Lieu,Jake T. Kline,Christopher Mullen,Kristina Srzentić,Romain Huguet,Graeme C. McAlister,Jingjing Huang,David Bergen,Rafael D. Melani,Vlad Zabrouskov,Kenneth R. Durbin,John E. P. Syka,Luca Fornelli

Analytical and Bioanalytical Chemistry（2024）

Cited 3|Views2

Key words

Orbitrap,Middle-down,IgG,Monoclonal antibody,mAb,ETD,HCD,EThcD,Proton transfer charge reduction,PTCR,Orbitrap Eclipse,Fourier transform mass spectrometry,FTMS

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