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Structure-guided Design and Synthesis of C22- and C32-modified FK520 Analogs with Enhanced Activity Against Human Pathogenic Fungi.

Patrick A. Dome,Pyeonghwa Jeong,Gibeom Nam, Hongjun Jang,Angela Rivera,Anna Floyd Averette,Eunchong Park,Tzu-Chieh Liao,Maria Ciofani,Jianli Wu,Jen-Tsan Ashley Chi,Ronald A. Venters,Hyun-Ju Park,William J. Steinbach,Praveen R. Juvvadi,Joseph Heitman,Jiyong Hong

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA（2025）

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关键词
calcineurin,FKBP12,FK506,antifungal
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