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Inhibition of RNA Splicing Triggers CHMP7 Nuclear Entry, Impacting TDP-43 Function and Leading to the Onset of ALS Cellular Phenotypes

Norah Al-Azzam, Jenny H. To, Vaishali Gautam,Lena A. Street, Chloe B. Nguyen,Jack T. Naritomi,Dylan C. Lam,Assael A. Madrigal, Benjamin Lee,Wenhao Jin, Anthony Avina,Orel Mizrahi,Jasmine R. Mueller, Willard Ford,Cara R. Schiavon, Elena Rebollo,Anthony Q. Vu,Steven M. Blue, Yashwin L. Madakamutil,Uri Manor,Jeffrey D. Rothstein,Alyssa N. Coyne,Marko Jovanovic,Gene W. Yeo

NEURON（2024）

Cited 1|Views0
Key words
neurodegeneration,amyotrophic lateral sclerosis,ALS,CHMP7,TDP-43,SMN complex,SmD1,CRISPR screen,RNA splicing
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