Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease

John Ryan Kerrigan,Noel M. Thomsen,Artiom Cernijenko,Sarah E. Kochanek, Janetta Dewhurst, Gary O'Brien,Nathaniel F. Ware, Carina C. Sanchez, James R. Manning,Xiaolei Ma,Elizabeth Ornelas, Nikolas A. Savage, James R. Partridge,Andrew W. Patterson, Philip Lam,Natalie A. Dales,Simone Bonazzi,Sneha Borikar, Amelia E. Hinman, Pamela Y. Ting

JOURNAL OF MEDICINAL CHEMISTRY（2024）

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