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Covalent Inhibitors of the RAS Binding Domain of PI3Ka Impair Tumor Growth Driven by RAS and HER2

Joseph E Klebba,Nilotpal Roy,Steffen M Bernard,Stephanie Grabow,Melissa A. Hoffman, Hui Miao, Junko Tamiya, Jinwei Wang, Cynthia Berry, Antonio Esparza-Oros, Richard Lin, Yongsheng Liu, Marie Pariollaud, Holly Parker, Igor Mochalkin,Sareena Rana,Aaron N. Snead, Eric J. Walton, Taylor E. Wyrick, Erick Aitichson, Karl Bedke, Jacyln C. Brannon,Joel M. Chick, Kenneth Hee,Benjamin D. Horning,Mohamed Ismail, Kelsey N. Lamb, Wei Lin, Justine Metzger,Martha K. Pastuszka, Jonathan Pollock,John J. Sigler,Mona Tomaschko,Eileen Tran,Todd M. Kinsella,Miriam Molina-Arcas,Gabriel M. Simon,David S. Weinstein,Julian Downward,Matthew P. Patricelli

biorxiv(2024)

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