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Solution Biophysics Identifies Lipid Nanoparticle Non-Sphericity, Polydispersity, and Dependence on Internal Ordering for Efficacious Mrna Delivery

Marshall S Padilla,Sarah J Shepherd, Andrew R Hanna, Martin Kurnik, Xujun Zhang, Michelle Chen, James Byrnes,Ryann A Joseph, Hannah M Yamagata,Adele S Ricciardi,Kaitlin Mrksich,David Issadore,Kushol Gupta,Michael J Mitchell

bioRxiv the preprint server for biology（2025）

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