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    • The Impact of Disease Activity Criteria on Extending Injection Intervals in Real-World Patients with Neovascular Age-Related Macular Degeneration.

    Bhairavi Bhatia,Sing Yue Sim,Evangelia Chalkiadaki, Georgios Koutsocheras,Luke Nicholson,Senthil Selvam,Sobha Sivaprasad,Bishwanath Pal,Josef Huemer,Pearse A. Keane,Robin Hamilton,Praveen J. Patel

    Ophthalmology and Therapy（2025）

    Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology

    Cited 0|Views2
    Abstract
    In clinical practice, intravitreal anti-vascular endothelial growth factor (anti-VEGF) injection intervals for patients with neovascular age-related macular degeneration (nAMD) are based on disease activity, with active or recurrent disease requiring more frequent injections. Injection interval modification criteria differ from those used in clinical trials, thereby potentially affecting treatment outcomes. This analysis evaluated the potential impact of applying disease activity criteria from recent clinical trials (TENAYA/LUCERNE; HAWK/HARRIER; PULSAR) on the decision to extend injection intervals in real-world patients commenced on faricimab after the loading phase of treatment and at 12 months. Data were analysed from 105 treatment-naïve patients with nAMD who received anti-VEGF injections at Moorfields Eye Hospital. Disease activity criteria from TENAYA/LUCERNE, HAWK/HARRIER and PULSAR clinical trials were applied to determine the hypothetical impact on the decision to modify injection intervals at week 12 (fourth injection) and 12-month real-world clinic visits. At 12 weeks, 79
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    Key words
    Anti-vascular endothelial growth factor (anti-VEGF),Neovascular age-related macular degeneration (nAMD),Optical coherence tomography (OCT),Real-world
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