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Continued Directed Evolution of VCAP-101 and VCAP-102 Identifies Second Generation Capsid Variants with Increased Brain Tropism and in Non-Human Primates and Mice

Tyler Moyer, Kristin Graham,Jiachen Liu,Xiaoqin Ren,Joseph Clement, Alexis Bloedel, Rebecca Spellman, Camila Arce, Hamza Khalid,Anupriya Kulkarni, Alexandra Tsolias, Rong Zhao, Wenya Yang,Amy Bruce, Chiso Egbuchulam, Tatianna Knox, Brett Hoffman, Ishan Shah, Michael Grannan,Charlotte Chung,Alexander Kutchin,Johnson Amy,Kyle Grant,Nilesh Pande,Jeff Thompson,Johnny Yao,Chanchal Sadhu, Todd A. Carter,Mathieu E. Nonnenmacher

MOLECULAR THERAPY(2024)

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