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CIROZ is Dispensable in Ancestral Vertebrates but Essential for Left-Right Patterning in Humans

Emmanuelle Szenker-Ravi,Tim Ott, Amirah Yusof,Maya Chopra,Muznah Khatoo, Beatrice Pak, Wei Xuan Goh,Anja Beckers,Angela F. Brady, Lisa J. Ewans, Nabila Djaziri,Naif A.M. Almontashiri,Malak Ali Alghamdi,Essa Alharby,Majed Dasouki, Lindsay Romo,Wen-Hann Tan,Sateesh Maddirevula,Fowzan S. Alkuraya, Jessica L. Giordano

The American Journal of Human Genetics（2025）

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Key words
CIROZ,C1orf127,evo-devo,laterality,heterotaxy,left-right organizer,CIROP,MMP21,DAND5,PKD1L1,gene loss,pseudogenization,motile cilia,ZP-N,ZP2
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