One-Step Fabrication of Highly Customizable Porous Core-Shell Microspheres for the Construction of a 3D Physiologically Relevant Perivascular-Endosteal Multi-Microenvironment Model of Breast Cancer Bone Metastasis

Meiying Hong, Guanxiong Wang, Menghan Yang,Hong Liu, Haisen Huang, Tiantian Liu, Siping Wang, Rui Shen, Huatao He,Yi Li, Ting Du,Xin Hao,Qingyun Xie, Chongyang Shen,Yaolei Wang

ADVANCED FUNCTIONAL MATERIALS（2025）

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Key words

aqueous two-phase emulsions,breast cancer bone metastasis,endosteal microenvironment,in vitro 3D cell culture,perivascular microenvironment,porous core-shell microspheres,vascularization

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