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POLE Mutation Associated with Microsatellite Instability and High Tumor Mutational Burden Confers Exquisite Sensitivity to Immune Checkpoint Inhibitor Therapy in Non-Small Cell Lung Cancer: a Case Report and Genomic Database Analysis

Matthew S. Lara, Jonathan W. Riess, Guneet Kaleka, Alexander Borowsky, John D. McPherson, Luis A. Godoy, Lorenzo Grego,Primo N Lara,Nicholas Mitsiades

Clinical Lung Cancer(2025)

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Key words
Non-small cell lung cancer,POLE mutation,tumor mutational burden,immunotherapy
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