Figure 5 from Complement Factor H is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment

Karolina I. Smolag,Jakub Olszowka,Rebecca Rosberg,Elinn Johansson, Elisabet Marinko,Karin Leandersson,David J. O’Connell,Valeria Governa,Emre Can Tuysuz,Mattias Belting,Alexander Pietras,Myriam Martin,Anna M. Blom

crossref（2025）

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Abstract

ICOS is associated with poor prognosis of patients with glioma. A, ICOS expression correlates with decreased survival of patients with glioma. Expression of ICOS correlates with neoplasm histological grade (B), cancer type (C), and EGFR mutations (D). ICOS positively correlates with infiltration of Tregs (E) and negatively with infiltration of CD8+ T cells (F) and CD4+ T cells (G) in lower-grade glioma. H, In a patient cohort stratified based on FH expression, ICOS correlates with worse survival only in the FH-high group. The survival estimates and correlation with other clinical parameters were analyzed in cBioPortal and based on the TCGA provisional dataset brain lower-grade glioma. The cases were set to include samples with mRNA data from n = 508 patients (A–D and H). Correlation analysis of the immune infiltration was performed using TIMER2.0, based on n = 516 samples from patients with lower-grade glioma. Statistical tests: logrank test (A–H), χ2 test (B and C), one-sided Fisher exact test (D), and Spearman’s rho correlation (E–G).

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【要点】：论文揭示了补体因子H（FH）作为T细胞免疫调节因子ICOS的配体，在胶质瘤微环境中调节调节性T细胞（Tregs），并与患者预后不良相关。

【方法】：通过分析TCGA数据库中的mRNA表达数据，以及使用TIMER2.0工具进行免疫细胞浸润的相关性分析，研究ICOS表达与胶质瘤患者生存率、肿瘤分级、癌症类型、EGFR突变以及T细胞浸润之间的关系。

【实验】：在包含508名患者mRNA数据的TCGA provisional数据集上，通过统计方法（包括logrank测试、χ2测试、Fisher精确检验和Spearman秩相关分析）分析ICOS表达与患者生存率和其他临床参数的关系，以及基于516名患者样本的免疫细胞浸润相关性。结果显示，ICOS在FH高表达组中与患者预后不良相关。