Pathogenic Variants of TUBB8 Cause Oocyte Spindle Defects by Disrupting with EB1/CAKP5 Interactions and Potential Treatment Targeting Microtubule Acetylation Through HDAC6 Inhibition

Hui Luo, Jianhua Chen, Cao Li, Tian Wu, Siyue Yin, Guangping Yang, Yipin Wang, Zhihan Guo,Saifei Hu, Yanni He, Yingnan Wang,Yao Chen,Youqiang Su,Congxiu Miao,Yun Qian,Ruizhi Feng

CLINICAL AND TRANSLATIONAL MEDICINE（2025）

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Key words

D417N variant,female infertility,meiotic arrest,oocyte,TUBB8

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