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Triple Knockdown of CD11a , CD49d , and PSGL1 in T Cells Reduces CAR-T Cell Toxicity but Preserves Activity Against Solid Tumors in Mice

Hongye Wang, Zhaorong Wu,Dan Cui,Linke Bian, Zhigang Zheng, Jiufei Zhu,Haigang Geng, Zhen Sun, Yixiao Pan,Yaoping Shi, Qiaoyong Yi,Zhenyu Song, Yantao Li,Kangjie Shen,Yuan Li, Weiming Shen,Hexin Yan,Ruidong Hao, Minmin Sun, Shuangshung Zhang,Chuanjie Zhang,Haojie Jin,Bo Zhai

SCIENCE TRANSLATIONAL MEDICINE(2025)

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