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Allosteric Regulation of Pyruvate Kinase Enables Efficient and Robust Gluconeogenesis by Preventing Metabolic Conflicts and Carbon Overflow.

Fukang She,Brent W. Anderson,Daven B. Khana,Shenwei Zhang,Wieland Steinchen,Danny K. Fung, Nathalie G. Lesser, Lauren N. Lucas,David M. Stevenson,Theresa J. Astmann,Gert Bange,Jan-Peter van Pijkeren,Daniel Amador-Noguez,Jue D. Wang

MSYSTEMS（2025）

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关键词
pyruvate kinase,gluconeogenesis,overflow metabolism,allosteric regulation
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