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Molecular Insights into Α-Synuclein Fibrillation: A Raman Spectroscopy and Machine Learning Approach

Nathan P. Coles, Suzan Elsheikh,Agathe Quesnel,Lucy Butler, Claire Jennings, Chaimaa Tarzi,Ojodomo J. Achadu,Meez Islam,Karunakaran Kalesh,Annalisa Occhipinti,Claudio Angione, Jon Marles-Wright,David J. Koss,Alan J. Thomas,Tiago F. Outeiro,Panagiota S. Filippou,Ahmad A. Khundakar

ACS CHEMICAL NEUROSCIENCE（2025）

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Key words
alpha-synuclein aggregation,Lewy body diseases,Raman spectroscopy,machinelearning analysis,beta-sheet formation,fibrillationpathway
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