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Redirecting Glucose Flux During in Vitro Expansion Generates Epigenetically and Metabolically Superior T Cells for Cancer Immunotherapy

Andrew T. Frisch,Yiyang Wang,Bingxian Xie, Aaron Yang,B. Rhodes Ford,Supriya Joshi, Katarzyna M. Kedziora,Ronal Peralta,Drew Wilfahrt,Steven J. Mullett,Kellie Spahr,Konstantinos Lontos, Jessica A. Jana, Victoria G. Dean, William G. Gunn, Stacy Gelhaus,Amanda C. Poholek,Dayana B. Rivadeneira,Greg M. Delgoffe

Cell Metabolism（2025）

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Key words
Immunometabolism,mitochondria,cell therapy,T cell,glucose,longevity,epigenetics,immunotherapy,CAR-T,metabolism
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