Further Optimization of the Mglu1 PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685

Carson W. Reed, Jacob F. Kalbfleisch, Jeremy A. Turkett, Trevor A. Trombley,Paul K. Spearing, Daniel H. Haymer,Marc Quitalig,Jonathan W. Dickerson,Daniel J. Foster,Annie L. Blobaum,Olivier Boutaud,Hyekyung P. Cho,Colleen M. Niswender,Jerri M. Rook, Henning Priepke, Heiko Sommer, Stefan Scheuerer,Daniel Ursu,P. Jeffrey Conn,Bruce J. Melancon,Craig W. Lindsley

ACS CHEMICAL NEUROSCIENCE（2025）

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Key words

metabotropic glutamate receptor subtype 1 (mGlu(1)),positive allosteric modulator (PAM),cognition,metabolism,amphetamine-induced hyperlocomotion,pharmacokinetics

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