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Ph-Dependent Dissociation from CTLA-4 in Early Endosomes Improves Both Safety and Antitumor Activity of Anti-Ctla-4 Antibodies.

Meiyu Zhang, Jinmei Li, Kepeng Yan, Haoyue Zhou, Song Mei, Benyu Wang, Dongyang Li,Xuexiang Du,Mingyue Liu,Peng Zhang,James K Fields, Lei Ye,Pan Zheng,Yang Liu,Michael J Lenardo,Yan Zhang

Proceedings of the National Academy of Sciences of the United States of America(2025)

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